Selected Publications:

Trinks A, Milek M, Beule D, Kluge J, Florian S, Sers C, Horst D, Morkel M*, Bischoff P*. Robust detection of clinically relevant features in single-cell RNA profiles of patient-matched fresh and formalin-fixed paraffin-embedded (FFPE) lung cancer tissue. Cellular Oncology. 2024 Feb 1; doi: 10.1007/s13402-024-00922-0

Sell T, Klotz C, Fischer MM, Astaburuaga-García R, Krug S, Drost J, Clevers H, Sers C, Morkel M*, Blüthgen N*. Oncogenic signalling is coupled to colorectal cancer cell differentiation state. J Cell Biol. 2023 Jun 5;222(6):e202204001

Uhlitz F, Bischoff P, Peidli S, Sieber A, Trinks A, Lüthen M, Obermayer B, Blanc E, Ruchiy Y, Sell T, Mamlouk S, Arsie R, Wei TT, Klotz-Noack K, Schwarz RF, Sawitzki B, Kamphues C, Beule D, Landthaler M, Sers C, Horst D, Blüthgen N*, Morkel M*. Mitogen-activated protein kinase activity drives cell trajectories in colorectal cancer. EMBO Mol Med. 2021 Oct 7;13(10):e14123 (on cover)

Farrall AL, Lienhard M, Grimm C, Kuhl H, Sluka SHM, Caparros M, Forejt J, Timmermann B, Herwig R, Herrmann BG*, Morkel M*. PWD/Ph-Encoded Genetic Variants Modulate the Cellular Wnt/β-Catenin Response to Suppress Apc Min-Triggered Intestinal Tumor Formation. Cancer Res. 2021 Jan 1;81(1):38-49.

Brandt, R, Uhlitz, F, Riemer, P, Giesecke, C, Schulze, S, El-Shimy, EA Fauler, B, Mielke, T, Mages, N, Herrmann, BG, Sers, C, Blüthgen, N*, Morkel, M*. Cell type-dependent differential activation of ERK by oncogenic KRAS in colon cancer and intestinal epithelium. Nat Commun. 2019 doi: 10.1038/s41467-019-10954-y (F1000 recommended)

Riemer P, Rydenfelt M, Marks M, van Eunen K, Thedieck K, Herrmann BG, Blüthgen N, Sers C, Morkel M. Oncogenic β-Catenin and PIK3CA instruct network states and cancer phenotypes in intestinal organoids. J Cell Biol., 2017 doi: 10.1083/jcb.201610058

Riemer P, Sreekumar A, Reinke S, Rad R, Schäfer R, Sers C, Bläker H, Herrmann BG, Morkel M. Transgenic expression of oncogenic BRAF induces loss of stem cells in the mouse intestine, which is antagonized by β-Catenin activity.  Oncogene 2015 Jun 11;34(24):3164-75.

Grimm C, Chavez L, Vilardell M, Farrall AL, Tierling S, Böhm JW, Grote P, Lienhard, Timmermann B, Walter J, Schweiger MR, Lehrach H, Herwig R, Herrmann BG, Morkel M. DNA-methylome analysis of mouse intestinal adenoma identifies a tumour-specific signature that is partly conserved in human colon cancer. PLoS Genetics 2013 Feb 7;9(2):e1003250

Farrall AL, Riemer P, Leushacke M, Sreekumar A, Grimm C, Herrmann BG, Morkel M. Wnt and BMP signals control intestinal adenoma cell fates. Int J Cancer 2012 Nov 15;131(10):2242-52

 

For a full list of publications, see https://orcid.org/0000-0002-2553-9999